SGK1 polyclonal Antibody | BS91236

SGK1 polyclonal Antibody | BS91236 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC IP FC

Application Range: WB:1:1,000 IHC:1:50-1:200 FC:1:50-1:100

Background: Serum- and glucocorticoid-regulated kinase (SGK), also known as SGK1, is a serine/threonine protein kinase and a member of the "AGC" subfamily, which includes protein kinases A, G, and C. SGK plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK contains a catalytic domain, which is most similar to Akt1 (also known as protein kinase B or PKB) . SGK is a downstream target of PI 3-kinase-stimulated growth factor signaling, with 3-phosphoinositide-dependent protein kinase 1 (PDK1) capable of phosphorylating the activation-loop of SGK at Threonine-256. The adrenal corticosteroid hormone, Aldosterone, induces the transcription of SGK, which mediates Na + transport by stimulating epithelial sodium channel activity. The SGK promoter contains a glucocorticoid response element and an SP-1 regulatory element, and is a transcriptional target for p53. SGK is also a component of the p38 MAPK-mediated response to hyperosmotic stress. The human SGK gene maps to chromosome 6q23 and encodes the 431-amino acid SGK protein.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SGK1 polyclonal Antibody detects endogenous levels of SGK1 protein.

Molecular Weight: 55 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SGK1, OTTHUMP00000017247, Serine/threonine protein kinase SGK, Serine/threonine protein kinase Sgk1, Serine/threonine-protein kinase Sgk1, Serum and glucocorticoid regulated kinase, Serum/glucocorticoid regulated kinase 1, Serum/glucocorticoid regulated kinase, Serum/glucocorticoid-regulated kinase 1, SGK 1, SGK, SGK1, Sgk1 variant i3, SGK1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: