SGOL2 Antibody (Center) [APR04515G]

SGOL2 Antibody (Center) [APR04515G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.

Cellular Localisation: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q7TSY8}. Note=During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity) . SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity) . During meiosis II, it shows a striking tension- dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity) . In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487) Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487) . {ECO:0000250|UniProtKB:Q7TSY8, ECO:0000269|PubMed:17485487}

Molecular Weight: 144739

Clone: Polyclonal

Gene Name: SGO2 (HGNC:30812)

Gene ID: 151246

Function: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity) . Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Shugoshin-like 2, Shugoshin-2, Sgo2, Tripin, SGOL2