SH-5 | 1818

A cell-permeable inhibitor of Akt activation without affecting the activation of the upstream kinase PDK1 or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt.

SH-5 is a cell-permeable inhibitor of Akt activation without affecting the activation of the upstream kinase PDK1 or other kinases downstream of Ras such as MAPK. Induces apoptosis and kills a variety of cancer cell lines containing high levels of active Akt.

1818 | SH-5 DataSheet

Alternate Name/Synonyms: D-3-Deoxy-2-O-methyl-myo-inositol 1-[(R)-2-methoxy-3-(octadecyloxy)propyl hydrogen phosphate

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 701976-54-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₉H₅₉O₁₀P

Molecular Weight: 598.75

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An Akt inhibitor

MDL Number: N/A

PubChem CID: 16760282

SMILES: CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OC1C(CC(C(C1O)O)O)OC)OC

InChi: InChI=1S/C29H59O10P/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-37-22-24(35-2)23-38-40(33,34)39-29-26(36-3)21-25(30)27(31)28(29)32/h24-32H,4-23H2,1-3H3,(H,33,34)/t24-,25?,26?,27?,28?,29?/m1/s1

InChi Key: NRLLDDPUQZQEDV-UXPKSZKYSA-N