Shb (phospho-Y246) polyclonal Antibody | BS4821

Shb (phospho-Y246) polyclonal Antibody | BS4821 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: IHC

Application Range: IHC: 1:50~1:200

Background: The SH2 (Src Homology 2) domain is a structurally conserved motif that contains two alpha helices and seven beta strands and is found in a variety of proteins that are involved in signal transduction throughout the cell. Specifically, the SH2 domain targets SH2 domain-containing proteins to tyrosinephosphorylated sites, an event that can trigger a protein-protein interaction cascade which may ultimately effect gene expression and cellular function. Shb (SH2 domain-containing adapter protein b), Shd (SH2 domain-containing adapter protein d), She (SH2 domain-containing adapter protein e) and Shf (SH2 domain-containing adapter protein f) are SH2 domain-containing proteins that play various roles throughout the cell.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Shb (Y246) polyclonal Antibody detects endogenous levels of Shb protein only when phosphorylated at Tyr246.

Molecular Weight: ~55kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SH2 domain-containing adapter protein B; SHB

Immunogen: Synthetic phosphopeptide derived from human Shb around the phosphorylation site of Tyrosine 246.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: