SHP1 polyclonal Antibody | BS91239

SHP1 polyclonal Antibody | BS91239 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC IHC

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Background: The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs) . Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: SHP1 polyclonal Antibody detects endogenous levels of SHP1 protein.

Molecular Weight: 68 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: PTP-1C, PTPN6, HCP, PTP1C, 70Z-SHP, EC 3.1.3.48, HCP, HCPH, Hematopoietic cell phosphatase, Hematopoietic cell protein tyrosine phosphatase, Hematopoietic cell protein-tyrosine phosphatase, HPTP1C, Protein tyrosine phosphatase 1C, Protein tyrosine phosphatase non receptor type 6, Protein tyrosine phosphatase SHP1, Protein-tyrosine phosphatase 1C, protein-tyrosine phosphatase SHP 1, Protein-tyrosine phosphatase SHP-1, PTN6, PTP 1C, PTP-1C, PTP1C, Ptpn6, SH PTP 1, SH PTP1, SH-PTP1, SHP 1, SHP 1L, SHP1, SHP1L, tyrosine protein phosphatase non receptor type 6, Tyrosine-protein phosphatase non-receptor type 6,

Immunogen: Synthetic peptide of C-terminal human SHP-1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Peptide affinity purified.

Pathway: B cell receptor signaling,