SIRT2 (D353) polyclonal Antibody | BS9174

SIRT2 (D353) polyclonal Antibody | BS9174 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: SIRT2 is a member of the sirtuin family of proteins. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. SIRT2 interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. SIRT2 is a NAD-dependent deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SIRT2 (D353) polyclonal Antibody detects endogenous levels of SIRT2 protein.

Molecular Weight: ~ 39, 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NAD-dependent protein deacetylase sirtuin-2; Regulatory protein SIR2 homolog 2; SIR2-like protein 2; SIRT2; SIR2L; SIR2L2

Immunogen: Synthetic peptide, corresponding to amino acids 320-373 of Human SIRT2.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Inhibition of Apoptosis,Mitochondrial Control of Apoptosis,