SIRT6 polyclonal Antibody | BS91248

SIRT6 polyclonal Antibody | BS91248 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF FC

Application Range: WB:1:1,000 FC:1:50-1:100 ICC:1:50-1:200

Background: The Silent Information Regulator (Sir2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD) -dependent protein deacetylases, also known as class III histone deacetylases. The first discovered and best characterized of this family is Saccharomyces cerevisiae Sir2, which is involved in silencing of mating type loci, telomere maintenance, DNA damage response, and cell aging. SirT6, a mammalian homolog of Sir2, is a nuclear, chromatin-associated protein that promotes the normal maintenance of genome integrity mediated by the base excision repair (BER) pathway. The BER pathway repairs single-stranded DNA lesions that arise spontaneously from endogenous alkylation, oxidation, and deamination events. SirT6 deficient mice show increased sensitivity to DNA-damaging agents, including the alkylating agents MMS and H2O2. In addition, these mice show genome instability with increased frequency of fragmented chromosomes, detached centromeres, and gaps. SirT6 may regulate the BER pathway by deacetylating DNA Polβ or other core components of the pathway.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SIRT6 polyclonal Antibody detects endogenous levels of SIRT6 protein.

Molecular Weight: 39 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SIRT6, 2810449N18Rik, AI043036, Mono ADP ribosyltransferase sirtuin 6, NAD-dependent protein deacetylase sirtuin-6, Regulatory protein SIR2 homolog 6, Regulatory protein SIR2 homolog, SIR2 like 6, SIR2 like protein 6, Sir2 related protein type 6, SIR2-like protein 6, SIR2L6, SIR6, SIRT 6, SIRT6, Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae), Sirtuin 6, Sirtuin type 6, Sirtuin6,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: