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Sirtinol | 2062

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SKU:
26-2062-GEN
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NULL282.00 - NULL567.00

Description

Cell-permeable. A selective sirtuin deacetylase inhibitor with IC50 values of 38, 68 and 131 μM for SIRT2, Sir2p and SIRT1 respectively. Sirtinol has no effect on HDAC1 activity. Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells.

Sirtinol is a selective sirtuin deacetylase inhibitor with IC50 values of 38, 68 and 131 μM for SIRT2, Sir2p and SIRT1 respectively. Sirtinol has no effect on HDAC1 activity. Sirtinol inhibits the growth of cancer cells and suppresses inflammatory signaling in human dermal microvascular endothelial cells.

2062 | Sirtinol DataSheet

Alternate Name/Synonyms: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide; Sir Two Inhibitor Naphthol

Appearance: Yellow solid

Formulation: N/A

CAS Number: 410536-97-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₆H₂₂N₂O₂

Molecular Weight: 394.47

Cell-Permeable?: Yes

Purity: ≥98%

Solubilities: DMSO (100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A selective sirtuin deacetylase inhibitor

MDL Number: MFCD00810186

PubChem CID: 5717148

SMILES: CC(C1=CC=CC=C1)NC(=O)C2=CC=CC=C2NC=C3C(=O)C=CC4=CC=CC=C43

InChi: InChI=1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,27H,1H3,(H,28,30)/b23-17-

InChi Key: YUGODMKHHCZZOI-QJOMJCCJSA-N

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Additional Information

Storage Condition:
-20°C
Shipping Condition:
Gel Pack
Shelf Life:
24 months
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