SIX1 Antibody (Center) [APR33306G]

SIX1 Antibody (Center) [APR33306G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This SIX1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 69-102 amino acids from the Central region of human SIX1.

Cellular Localisation: Nucleus. Cytoplasm

Molecular Weight: 32210

Clone: Polyclonal

Gene Name: SIX1

Gene ID: 6495

Function: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (By similarity) . Plays an important role in the development of several organs, including kidney, muscle and inner ear (By similarity) . Depending on context, functions as transcriptional repressor or activator (By similarity) . Lacks an activation domain, and requires interaction with EYA family members for transcription activation (PubMed:15141091) . Mediates nuclear translocation of EYA1 and EYA2 (PubMed:19497856) . Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (PubMed:27923061, PubMed:23435380, PubMed:15141091, PubMed:19497856) . Regulates the expression of numerous genes, including MYC, CCND1 and EZR (By similarity) . Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2 (By similarity) . Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (By similarity) . During myogenesis, seems to act together with EYA2 and DACH2 (By similarity) . Regulates the expression of CCNA1 (PubMed:15123840) . Promotes brown adipocyte differentiation (By similarity) .

Summary: Tissue Location: Specifically expressed in skeletal muscle.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Homeobox protein SIX1, Sine oculis homeobox homolog 1, SIX1