SKF-86002 | 2894

SKF-86002 is a p38 MAP kinase inhibitor (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO).

SKF-86002 is a p38 MAP kinase inhibitor (IC₅₀ = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC₅₀ = 1 μM). Also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO).

2894 | SKF-86002 DataSheet

Alternate Name/Synonyms: 6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole

Appearance: Off-white solid

Formulation: N/A

CAS Number: 72873-74-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₂F₃FS

Molecular Weight: 297.35

Cell-Permeable?: yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A p38 MAP kinase inhibitor

MDL Number: MFCD00869367

PubChem CID: 5228

SMILES: C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F

InChi: InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2

InChi Key: YOELZIQOLWZLQC-UHFFFAOYSA-N