SLC25A12 polyclonal Antibody | BS5616

SLC25A12 polyclonal Antibody | BS5616 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Calcium signaling in mitochondria is important in order for it to function in response to a variety of extracellular stimuli. Signaling begins with Ca (2+) entry in mitochondria via the Ca (2+) uniporter followed by Ca (2+) activation of three dehydrogenases in the mitochondrial matrix. ARALAR, the neuronal Ca (2+) -binding mitochondrial aspartate-glutamate carrier, has Ca (2+) binding domains facing the extramitochondrial space and functions in the malate-aspartate NADH shuttle (MAS) . ARALAR is encoded by the SLC25A12 gene and is expressed in brain and skeletal muscle. ARALAR is required for the synthesis of brain aspartate and N-acetylaspartatemay and plays a role in myelin formation. It is also essential for the transmission of small Ca (2+) signals to mitochondria via an increase in mitochondrial NADH. In addition, ARALAR is implicated in conferring susceptibility to schizophrenia.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SLC25A12 polyclonal Antibody detects endogenous levels of SLC25A12 protein.

Molecular Weight: ~ 74 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12; ARALAR1

Immunogen: Synthetic peptide, corresponding to amino acids 435-480 of Human SLC25A12.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: ErbB HER Signaling,