Smac/DIABLO Antibody [2D12] | 99-765

Smac/DIABLO Antibody [2D12] | 99-765 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human

Homology: N/A

Immunogen: Recombinant Smac/DIABLO

Research Area: Transcription, Cancer

Tested Application: WB, IHC-Fr, Flow

Application: Smac/DIABLO Antibody [2D12] for use in ELISA and western blotting assays.

Specificiy: Smac/DIABLO

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: N/A

Validation: N/A

Isoform: N/A

Purification: N/A

Clonality: Monoclonal

Clone: [2D12]

Isotype: IgG2b

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Supplied in borate buffered saline, pH 8.2; No preservatives or amine-containing buffer salts added

Concentration: 0.5 mg/mL

Storage Condition: Store vial at 2-8˚C

Alternate Name: SMAC3, DIABLO-S, FLJ10537, FLJ25049, 0610041G12Rik

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Smac/DIABLO (second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI) is a mitochondrial protein that functions as a regulatory component during apoptosis. It is encoded by a nuclear gene and is subsequently imported into the mitochondria where the N-terminus is removed generating the mature form of the molecule. Smac/DIABLO has been shown to neutralize the antiapoptotic effect of the inhibitor of apoptosis protein (IAP) family, a major group of apoptosis regulators that have been shown to directly block caspase activity thereby blocking apoptosis.