SMC1 polyclonal Antibody | BS91258

SMC1 polyclonal Antibody | BS91258 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB ICC/IF IHC

Application Range: WB:1:1,000-1:2,000 ICC:1:100-1:500 IHC:1:50-1:200

Background: The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. SMC1α (structural maintenance of chromosomes protein 1A), also known as SMC1, SMCB, CDLS2, SB1.8, SMC1L1 or DXS423E, is a 1,233 amino acid nuclear protein that is involved in chromosome cohesion during the cell cycle. SMC1α interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role in DNA repair. SMC1α is a component of the cohesion complex, which is required for the cohesion of sister chromatids after DNA replication. Mutations in the gene encoding SMC1α may be the cause of Cornelia de Lange syndrome (CdLS), which is a clinically heterogeneous developmental disorder characterized by facial dysmorphia, upper limb malformations, growth and cognitive retardation.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SMC1 polyclonal Antibody detects endogenous levels of SMC1 protein.

Molecular Weight: 143 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1A, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B, CDLS2, DKFZp686L19178, DXhXs423e, DXS423E, KIAA0178, MGC138332, OTTHUMP00000061876, RP6 29D12.1, SB1.8, Segregation of mitotic chromosomes 1, Segregation of mitotic chromosomes like 1, SMC 1, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1, SMC1A, SMC1alpha, SMC1alpha protein, SMC1B, SMC1B, SMC1BETA, SMC1beta protein, SMC1L1, SMC1L2, SMCB, Structural maintenance of chromosome 1 like 1 protein, Structural maintenance of chromosome 1 like 2 protein, Structural maintenance of chromosomes 1A, Structural maintenance of chromosomes 1B, Structural maintenance of chromosomes protein 1B,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: