SMCR7L Antibody (N-term) [APR05657G]

SMCR7L Antibody (N-term) [APR05657G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This SMCR7L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-132 amino acids from the N-terminal region of human SMCR7L.

Cellular Localisation: Mitochondrion outer membrane; Single-pass membrane protein

Molecular Weight: 51293

Clone: Polyclonal

Gene Name: MIEF1

Gene ID: 54471

Function: Mitochondrial outer membrane protein which regulates mitochondrial fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L.

Summary: Tissue Location: Expression is relatively high in heart, skeletal muscle, pancreas and kidney.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Mitochondrial dynamics protein MID51, Mitochondrial dynamics protein of 51 kDa, Mitochondrial elongation factor 1, Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like, SMCR7-like protein, MIEF1, MID51, SMCR7L