SMO Antibody (Center) [APR31393G]

SMO Antibody (Center) [APR31393G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SMO antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-567 amino acids from the Central region of human SMO.

Cellular Localisation: Membrane; Multi- pass membrane protein. Cell projection, cilium

Molecular Weight: 86397

Clone: Polyclonal

Gene Name: SMO

Gene ID: 6608

Function: G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO) . Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253) . Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Smoothened homolog, SMO, Protein Gx, SMO, SMOH