SNAI1 (phospho Ser246) Antibody | 79-827

SNAI1 (phospho Ser246) Antibody | 79-827 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse

Homology: N/A

Immunogen: SNAI1 (phospho Ser246) antibody was raised against a peptide sequence around phosphorylation site of Serine 246 (T-F-S (p) -R-M) derived from Human SNAI1.

Research Area: Phospho-Specific

Tested Application: WB, IF

Application: Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Specificiy: The antibody detects endogenous levels of SNAI1 only when phosphorylated at serine 246.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 29 kDa

Validation: N/A

Isoform: N/A

Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Concentration: 1 mg/mL

Storage Condition: Store antibody at -20˚C for up to one year.

Alternate Name: SNAH, SNAI, Sna, Snail

User Note: N/A

BACKGROUND: Involved in induction of the epithelial to mesenchymal transition (EMT) , formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA) -induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.