SNX2 Antibody (C-term) [AMM07913G]

SNX2 Antibody (C-term) [AMM07913G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-485 amino acids from the C-terminal region of human SNX2.

Cellular Localisation: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323) . Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901) .

Molecular Weight: 58471

Clone: Polyclonal

Gene Name: SNX2

Gene ID: 6643

Function: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns (3P) ) or phosphatidylinositol 3, 5-bisphosphate (PtdIns (3, 5) P2) (PubMed:16179610) . Acts in part as component of the retromer membrane- deforming SNX-BAR subcomplex (PubMed:17101778) . The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable) . Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988) . Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391) . Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Sorting nexin-2, Transformation-related gene 9 protein, TRG-9, SNX2