SNX6 Antibody (N-term) [APR03987G]

SNX6 Antibody (N-term) [APR03987G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SNX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the N-terminal region of human SNX6.

Cellular Localisation: Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle. Cytoplasm. Nucleus. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774) . Only a minor proportion is seen in the nucleus.

Molecular Weight: 46649

Clone: Polyclonal

Gene Name: SNX6

Gene ID: 58533

Function: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3, 4-bisphosphate and/or phosphatidylinositol 4, 5-bisphosphate (Probable) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774) . The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable) . Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988) . Involved in retrograde endosome- to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574) . May function as link between transport vesicles and dynactin (Probable) . Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142) . Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942) . In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity) . May contribute to transcription regulation (Probable) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Sorting nexin-6, TRAF4-associated factor 2, Sorting nexin-6, N-terminally processed, SNX6