SOCS7 Antibody| F45339-0.08ML/F45339-0.4ML/R33377-100UG

SOCS7 Antibody| F45339-0.08ML/F45339-0.4ML/R33377-100UG | Gentaur UK, US & Europe Distribution

Background: Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the SOCS7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This SOCS7 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 458-486 from the human protein was used as the immunogen for this SOCS7 antibody.

Storage: Aliquot the SOCS7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A