SOX10 Antibody | 8481

SOX10 Antibody | 8481 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Pig: (100%) , Chicken: (89%) , Goat: (100%)

Immunogen: SOX10 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human SOX10.

Research Area: Signal Transduction, Stem Cell

Tested Application: E, WB, IHC-P, IF

Application: SOX10 antibody can be used for Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: SOX10 Antibody is predicted to not cross-react with other SOX familiy members.

Positive Control 1: Cat. No. 1461 - Rat Heart Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 51 kDa
Observed: 54 kDa

Validation: N/A

Isoform: N/A

Purification: SOX10 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: SOX10 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: SOX10 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alternate Name: SOX10 Antibody: SRY (sex determining region Y) -box 10, DOM, WS4, PCWH, WS2E, WS4C

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: SOX10 Antibody: SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of the cell fate (1) . The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins (2) . This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development (2) . Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschprung disease (3) . SLC30A8 expression in beta-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4) .