SOX30 Antibody (Center) [APR05736G]

SOX30 Antibody (Center) [APR05736G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SOX30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 373-403 amino acids from the Central region of human SOX30.

Cellular Localisation: Nucleus. Cytoplasm Note=Enriched at the chromocenter. {ECO:0000250|UniProtKB:Q8CGW4}

Molecular Weight: 81854

Clone: Polyclonal

Gene Name: SOX30

Gene ID: 11063

Function: Acts as both a transcriptional activator and repressor (PubMed:10359848, PubMed:29739711) . Binds to the DNA sequence 5'-ACAAT- 3' and shows a preference for guanine residues surrounding this core motif (PubMed:10359848) . Binds to its own promoter and activates its own transcription (By similarity) . Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity) . Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711) . Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (PubMed:29739711) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Transcription factor SOX-30, SOX30