SRY Antibody (Center) [ApR04854G]

SRY Antibody (Center) [ApR04854G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SRY antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 81-112 amino acids from the Central region of human SRY.

Cellular Localisation: Nucleus speckle. Cytoplasm. Nucleus Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (PubMed:15297880) . Colocalizes with SOX6 in speckles (PubMed:11818535) Colocalizes with CAML in the nucleus (PubMed:15746192) . Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) . {ECO:0000250|UniProtKB:Q05738, ECO:0000269|PubMed:11818535, ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15746192}

Molecular Weight: 23884

Clone: Polyclonal

Gene Name: SRY {ECO:0000303|PubMed:1695712, ECO:0000312|HGNC:HGNC:11311}

Gene ID: 6736

Function: Transcriptional regulator that controls a genetic switch in male development (PubMed:11563911) . It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16996051, PubMed:16414182) . Involved in different aspects of gene regulation including promoter activation or repression (PubMed:9525897) . Binds to the DNA consensus sequence 5'- [AT]AACAA[AT]-3' (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344) . SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344, PubMed:16762365) . Also involved in pre-mRNA splicing (PubMed:11818535) . In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Sex-determining region Y protein, Testis-determining factor, SRY, TDF