SSRP1 polyclonal Antibody | BS8198

SSRP1 polyclonal Antibody | BS8198 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse

Application: WB IHC IF

Application Range: WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100

Background: Expression of protein-coding genes requires the association of specific transcription factors, RNA polymerase and various accessory factors (1) . These accessory factors are distinguished as either histone acetyltransferases or ATP-dependent chromatin-remodeling enzymes, which include FACT (for facilitates chromatin transcription), and they facilitate transcription initiation on DNA packaged into chromatin. FACT is a chromatin-specific elongation factor required for transcription of chromatin templates, and it specifically interacts with nucleosomes and histone H2A/H2B dimers, to promote nucleosome disassembly upon transcription. FACT represents a complex between SPT16, a homologue of the Saccharomyces cerevisiae Spt16/Cdc68 protein, and the high-mobility group (HMG) -1-like protein structure-specific recognition protein-1 (SSRP-1) . Similar to other (HMG) domain containing proteins, which are characterized by their ability to bend target DNAs, SSRP1 and the murine ortholog T160, physically interact with serum response factors (SRF) and function as positive co-regulatory proteins involved in modulating SRF-dependent gene expression .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SSRP1 polyclonal Antibody detects endogenous levels of SSRP1 protein.

Molecular Weight: ~ 98 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: FACT complex subunit SSRP1; Chromatin-specific transcription elongation factor 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; FACT 80 kDa subunit; FACTp80; Facilitates chromatin transcription complex subunit; SSRP1; Recombination signal sequence recognition protein 1; Structure-specific recognition protein 1; hSSRP1; T160; SSRP1; FACT80

Immunogen: Recombinant full length Human SSRP1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: