STA-21 | 2626

STA-21 is a natural antibiotic that acts as a selective STAT3 inhibitor. It inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM. It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC₅₀ = 12.2 μM). It reciprocally regulates Th17 and Treg cells, and inhibits osteoclast formation.

STA-21 is a natural antibiotic that acts as a selective STAT3 inhibitor. It inhibits STAT3 by preventing its dimerization and DNA binding when used at concentrations of 20-30 μM. It blocks the growth and survival of cancer cells that express constitutively active STAT3 (e.g., DU145 cells, IC₅₀ = 12.2 μM). It reciprocally regulates Th17 and Treg cells, and inhibits osteoclast formation.

2626 | STA-21 DataSheet

Alternate Name/Synonyms: ((3S)-​3,​4-​dihydro-​8-​hydroxy-​3-​methyl-​benz[a]anthracene-​1,​7,​12(2H)-​trione; Ochromycinone

Appearance: Light orange solid

Formulation: N/A

CAS Number: 28882-53-3

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₄O₄

Molecular Weight: 306.31

Cell-Permeable?: Yes

Purity: >98%

Solubilities: DMSO (~ 15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A STAT3 inhibitor

MDL Number: N/A

PubChem CID: 11808929

SMILES: CC1CC2=C(C(=O)C1)C3=C(C=C2)C(=O)C4=C(C3=O)C=CC=C4O

InChi: InChI=1S/C19H14O4/c1-9-7-10-5-6-12-17(15(10)14(21)8-9)19(23)11-3-2-4-13(20)16(11)18(12)22/h2-6,9,20H,7-8H2,1H3/t9-/m0/s1

InChi Key: ZAWXOCUFQSQDJS-VIFPVBQESA-N