STAT3 Inhibitor, C188-9 | B2386

C188-9 is a potent STAT3 inhibitor that binds to STAT3 with high affinity (Kd of 4.7 nM). C188-9 has the ability to inhibit STAT3 binding to its pY-peptide ligand, to inhibit cytokine-stimulated pSTAT3, to reduce constitutive pSTAT3 activity in multiple HNSCC cell lines, and to inhibit anchorage dependent and independent growth of these cells.

C188-9 is a potent STAT3 inhibitor that binds to STAT3 with high affinity (Kd of 4.7 nM). C188-9 has the ability to inhibit STAT3 binding to its pY-peptide ligand, to inhibit cytokine-stimulated pSTAT3, to reduce constitutive pSTAT3 activity in multiple HNSCC cell lines, and to inhibit anchorage dependent and independent growth of these cells.

B2386 | STAT3 Inhibitor, C188-9 DataSheet

Alternate Name/Synonyms: F1113-0789, N-(1ʹ,2-Dihydroxy-1,2ʹ-binaphthalen-4ʹ-yl)-4-methoxybenzenesulfonamide

Appearance: Off-white solid

Formulation:

CAS Number: 432001-19-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₇H₂₁NO₅S

Molecular Weight: 471.52

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A STAT3 inhibitor

MDL Number:

PubChem CID: 1324494

SMILES: COC1=CC=C(C=C1)S(=O)(=O)NC2=CC(=C(C3=CC=CC=C32)O)C4=C(C=CC5=CC=CC=C54)O

InChi: InChI=1S/C27H21NO5S/c1-33-18-11-13-19(14-12-18)34(31,32)28-24-16-23(27(30)22-9-5-4-8-21(22)24)26-20-7-3-2-6-17(20)10-15-25(26)29/h2-16,28-30H,1H3

InChi Key: QDCJDYWGYVPBDO-UHFFFAOYSA-N