STAT5B Antibody | 13-121

STAT5B Antibody | 13-121 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Rat

Homology: N/A

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human STAT5B (NP_036580.2) .

Research Area: Cancer, Immunology, Signal Transduction, Transcription

Tested Application: WB, IF

Application: WB: 1:500 - 1:2000
IF: 1:20 - 1:50

Specificiy: N/A

Positive Control 1: K-562

Positive Control 2: PC-12

Positive Control 3: MCF7

Positive Control 4: HepG2

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Observed: 95kDa

Validation: N/A

Isoform: N/A

Purification: Affinity purification

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Concentration: N/A

Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.

Alternate Name: STAT5B, STAT5

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.