Stattic | 2625

Stattic is a small molecule that selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC₅₀ = 5.1 μM at 37°C). Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.

Stattic is a small molecule that selectively inhibits STAT3 activation, dimerization, and nuclear translocation by preventing the binding of tyrosine-phosphorylated peptide motifs to the STAT3 SH2 domain (IC₅₀ = 5.1 μM at 37°C). Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. At 10 μM, stattic induces apoptosis in STAT3-dependent breast cancer (MDA-MB-231 and MDA-MB-435S) cell lines.

2625 | Stattic DataSheet

Alternate Name/Synonyms: 6-​Nitro-​1,​1-​dioxide-​benzo[b]thiophene; Stat3 Inhibitor V

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 19983-44-9

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₈H₅NO₄S

Molecular Weight: 211.19

Cell-Permeable?: Yes

Purity: >98%

Solubilities: DMSO (~ 25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A STAT3 inhibitor

MDL Number: MFCD00173799

PubChem CID: 2779853

SMILES: C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

InChi: InChI=1S/C8H5NO4S/c10-9(11)7-2-1-6-3-4-14(12,13)8(6)5-7/h1-5H

InChi Key: ZRRGOUHITGRLBA-UHFFFAOYSA-N