STIM1 polyclonal Antibody | BS91296

STIM1 polyclonal Antibody | BS91296 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC IP

Application Range: WB:1:1,000 IHC:1:50-1:200

Background: Ca2+ influx is essential for a variety of cellular functions including, secretion and transcription. Stromal interaction molecule 1 (Stim1) is a ubiquitously expressed cell surface transmembrane glycoprotein that plays a role in medi-ating Ca2+ influx following the depletion of intracellular Ca2+ stores. Stim1 functions in the endoplasmic reticulum (ER) where it acts as a Ca2+ sensor via its EF-hand domain which causes large conformational changes. When Ca2+ levels drop, Stim1 translocates from the ER to the plasma membrane, where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A/Orai1. Stim2 is a potent inhibitor of Stim1-mediated store-operated calcium (SOC) entry. Stim1 is implicated in tumor growth suppression and stromal-hematopoietic cell interactions.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: STIM1 polyclonal Antibody detects endogenous levels of STIM1 protein.

Molecular Weight: 100 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: STIM1, D11S4896E, GOK, OTTHUMP00000164512, OTTHUMP00000229140, OTTHUMP00000230742, SIM, STIM 1, STIM1, Stim1 stromal interaction molecule 1, STIM1, STIM1L, Stromal interaction molecule 1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: