STING Antagonist, H-151 | B2395

H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.

STING antagonist, H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-/- mice.

B2395 | STING Antagonist, H-151 DataSheet

Alternate Name/Synonyms: H151, H-151, N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea

Appearance: Off-white solid

Formulation:

CAS Number: 941987-60-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₇H₁₇N₃O

Molecular Weight: 279.34

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A STING antagonist

MDL Number:

PubChem CID: 7616033

SMILES: CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32

InChi: InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)

InChi Key: UJZDIKVQFMCLBE-UHFFFAOYSA-N