STX4 Antibody (Center) [APR13589G]

STX4 Antibody (Center) [APR13589G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This STX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-160 amino acids from the Central region of human STX4.

Cellular Localisation: Cell membrane {ECO:0000250|UniProtKB:Q08850}; Single-pass type IV membrane protein. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q08850}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000250|UniProtKB:Q08850}

Molecular Weight: 34180

Clone: Polyclonal

Gene Name: STX4

Gene ID: 6810

Function: Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity) . Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity) . In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (By similarity) . Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity) .

Summary: Tissue Location: Expressed in neutrophils and neutrophil- differentiated HL-60 cells. Expression in neutrophils increases with differentiation.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Syntaxin-4, Renal carcinoma antigen NY-REN-31, STX4, STX4A