SUFU polyclonal Antibody | BS91299

SUFU polyclonal Antibody | BS91299 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC IHC

Application Range: WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Background: Su (fu) (for Suppressor-of-Fused) is a key negative regulator in the vertebrate Hedgehog signaling pathway. Su (fu) interacts with genes encoding proteins in this signal transduction pathway. In Drosophila, Intracellular transduction of the Hedgehog pathway involves the release of a large complex containing Su (fu) . Su (fu) inhibits the activity of the transcription factor Gli1 and interacts with Gli2, Gli3 and the serine/threonine kinase Fused. Su (fu) is widely expressed in adult and embryonic tissues with higher expression in tissues patterned by hegdehog signaling. The Su (fu) gene locus maps to a region that is deleted in glioblastomas, prostate cancer, malignant melanoma and endometrial cancer.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: SUFU polyclonal Antibody detects endogenous levels of SUFU protein.

Molecular Weight: 54 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SUFUH, OTTHUMP00000020374, OTTHUMP00000020377, OTTHUMP00000020379, PRO1280, SU FU, SU (F) U, Su (fu), SUFU, SUFU negative regulator of hedgehog signaling, SUFU, SUFUH, SUFUXL, Suppressor of fused homolog (Drosophila), Suppressor of fused homolog,

Immunogen: Recombinant protein with human SUFU aa 1-250.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Protein affinity purified.

Pathway: