Survivin polyclonal Antibody | BS91304

Survivin polyclonal Antibody | BS91304 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF IHC FC

Application Range: WB:1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Background: The baculovirus protein p35 inhibits virally-induced apoptosis of invertebrate and mammalian cells and may function to impair the clearing of virally infected cells by the immune system of the host. This is accomplished at least in part by the ability of p35 to block both TNF- and FAS-mediated apoptosis through the inhibition of the ICE family of serine proteases. Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino-terminal baculovirus IAP repeat (BIR) motif and a carboxy-terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FAS-mediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivin-microtubule interactions occurs.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Survivin polyclonal Antibody detects endogenous levels of Survivin protein.

Molecular Weight: 16 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: BIRC5, API4, IAP4, API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Apoptosis inhibitor4, Baculoviral IAP repeat containing 5, Baculoviral IAP repeat containing protein 5, Baculoviral IAP repeat-containing protein 5, BIRC 5, BIRC5, BIRC5, EPR 1, IAP4, Survivin variant 3 alpha, SVV, TIAP,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: