Syk Inhibitor | 1983

Cell-permeable. An oxindole derivative that acts as a potent, reversible, and ATP-competitive Spleen tyrosine kinase (Syk) inhibitor (IC₅₀ = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC₅₀ = 313 nM).

Syk inhibitor is an oxindole derivative that acts as a potent, reversible, and ATP-competitive Spleen tyrosine kinase (Syk) inhibitor (IC₅₀ = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC₅₀ = 313 nM).

1983 | Syk Inhibitor DataSheet

Alternate Name/Synonyms: Spleen Tyrosine Kinase Inhibitor

Appearance: Orange solid

Formulation: N/A

CAS Number: 622387-85-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₅N₃O₃S

Molecular Weight: 353.39

Cell-Permeable?: Yes

Purity: ≥97% by HPLC (sum of two isomers)

Solubilities: DMSO

Handling: Protect from light and mositure

Country of Origin: USA

Tag Line: A potent and reversible Syk inhibitor

MDL Number: MFCD07776820

PubChem CID: 6419747

SMILES: CN1C=C(C2=CC=CC=C21)C=C3C4=C(C=CC(=C4)S(=O)(=O)N)NC3=O

InChi: InChI=1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19, 23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)/b15-8-

InChi Key: MLKHXLFEYOOYEY-NVNXTCNLSA-N