Symmetric DiMethyl-Histone H3-R17 Polyclonal Antibody | E-AB-67548

Symmetric DiMethyl-Histone H3-R17 Polyclonal Antibody | E-AB-67548 | Gentaur UK, US & Europe Distribution

Type: Methylated antibody

Synonyms: HIST1H3J, H3/j, H3FJ

Application: WB, IHC, IF

Reactivity: Human, Mouse, Rat

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Epigenetics and Nuclear Signaling

Background: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.

Concentration: 1 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: A synthetic methylated peptide corresponding to residues surrounding Arg17 of human histone H3

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Purification Method: Affinity purification

Dilution: WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 15 kDa

Molecular Weight(Observed): 17 kDa