Synaptotagmin 1/2 (phospho-T202/199) polyclonal Antibody | BS4191

Synaptotagmin 1/2 (phospho-T202/199) polyclonal Antibody | BS4191 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: Synaptotagmins are a large gene family of synaptic vesicle type III integral membrane proteins that function as regulators of both exocytosis and endocytosis and are involved in neurotransmitter secretion from small secretory vesicles. Calcium binds to Synaptotagmin I which triggers neurotransmitter release at the synapse. Synaptotagmin II is phosphorylated by WNK1 in a process that regulates calcium-dependent interactions. Synaptotagmin III is involved in calcium-dependent exocytosis of secretory vesicles in endocrine cells and neurons. Synaptotagmin IV is expressed in neuronal tissues, and has the highest mRNA levels in the hippocampus.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Synaptotagmin 1/2 (T202/199) polyclonal Antibody detects endogenous levels of Synaptotagmin 1/2 protein only when phosphorylated at SerT202/199.

Molecular Weight: ~ 60 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Synaptotagmin-1; Synaptotagmin 1; Synaptotagmin I; SytI; SYT1; SVP65; SYT; Synaptotagmin-2; Synaptotagmin 2; Synaptotagmin II; SytII; SYT2

Immunogen: Synthetic phosphopeptide derived from human Synaptotagmin 1 around the phosphorylation site of Threonine 202.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A