TAB1 Polyclonal Antibody | E-AB-15186

TAB1 Polyclonal Antibody | E-AB-15186 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: 2310012M03Rik, 3'-Tab1, MAP3K7IP 1, MAP3K7IP1, MGC57664, Mitogen activated protein kinase kinase kinase 7 interacting protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TAB 1, TAB1, TAB1, TAK1 binding protein 1, TAK1-binding protein 1, TGF beta activated kinase 1 binding protein 1, TGF-beta activated kinase 1/MAP3K7 binding protein 1, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, TGF-beta-activated kinase 1-binding protein 1, Transforming growth factor beta activated kinase binding protein 1

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Immunology, Signal Transduction

Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1.

Concentration: 0.2 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Recombinant protein of human TAB1

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification Method: Affinity purification

Dilution: IHC 1:50-1:200

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A