TAGAP polyclonal Antibody | BS61462

TAGAP polyclonal Antibody | BS61462 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: TAGAP (T-cell activation Rho GTPase-activating protein) is a 731 amino acid protein that contains one Rho-GAP domain and exists as 4 alternatively spliced isoforms. TAGAP mayfunction as a GTPase-activating protein and may play important roles during T-cell activation. The gene that encodes TAGAP contains approximately 10,685 bases andmapsto human chromosome 6q25.3. Making up nearly 6% of the human genome,chromosome 6 contains around 1,200 geneswithin 170million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is as sociatedwith early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is as sociated with chromosome 6 through the HFE gene. Notably, the PARK2 gene, which is associated with Parkinson’s disease, and the genes encoding the major histocompatiblity complex proteins, are also located on chromosome 6. In addition, Stickler syndrome, hydroxylase deficiency andmaple syrup urine disease are associated with genes on chromosome 6, while a bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TAGAP polyclonal Antibody detects endogenous levels of TAGAP protein.

Molecular Weight: ~ 82 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: T-cell activation Rho GTPase-activating protein; T-cell activation GTPase-activating protein; TAGAP; TAGAP1; FKSG15

Immunogen: Synthetic peptide, corresponding to amino acids 186-231 of Human TAGAP.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: