TAK-901 | B1945

TAK-901 is a potent inhibitor of Aurora kinases A and B with IC₅₀ value of 21 nM and 15 nM, respectively. Displays antineoplastic activity.

TAK-901 is a potent inhibitor of Aurora kinases A and B with IC₅₀ value of 21 nM and 15 nM, respectively. Displays antineoplastic activity.

B1945 | TAK-901 DataSheet

Alternate Name/Synonyms: 5-(3-ethylsulfonylphenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 934541-31-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₈H₃₂N₄O₃S

Molecular Weight: 504.64

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of Aurora kinases A and B

MDL Number: N/A

PubChem CID: 16124208

SMILES: CCS(=O)(=O)C1=CC=CC(=C1)C2=CC(=C(C3=C2C4=CC(=CN=C4N3)C)C)C(=O)NC5CCN(CC5)C

InChi: InChI=1S/C28H32N4O3S/c1-5-36(34,35)21-8-6-7-19(14-21)23-15-22(28(33)30-20-9-11-32(4)12-10-20)18(3)26-25(23)24-13-17(2)16-29-27(24)31-26/h6-8,13-16,20H,5,9-12H2,1-4H3,(H,29,31)(H,30,33)

InChi Key: WKDACQVEJIVHMZ-UHFFFAOYSA-N