TAL1 (Acetyl-K221/K222) polyclonal Antibody | BS64094

TAL1 (Acetyl-K221/K222) polyclonal Antibody | BS64094 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Activation of TAL1 characterizes up to 60% ofcases of human T cell acute lymph oblastic leukemia,making it themost frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phospho protein and basic helixx-loop-helixtranscription factorknown to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box.In addition, leukemogenesisis accelerated dramatically bytransgenic coexpression of TAL1 and the catalyticsubunit ofcasein kinase IIα, a serine/threonine protein kinase known tomodulate the activity of other βHLH transcription factors.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TAL1 (Acetyl-K221/K222) polyclonal Antibody detects endogenous levels of TAL1 protein only when acetylated at Lys221 and Lys222. This Antibody also recognizes TAL2 protein when acetylated at Lys36 and Lys37.

Molecular Weight: ~ 34 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL1;T-cell acute lymphocytic leukemia protein 2; TAL-2; Class A basic helix-loop-helix protein 19; bHLHa19; TAL2

Immunogen: Synthetic Acetylated peptide derived from human TAL1 around the Acetylation site of K221/K222.

Conjugate: Unconjugated

Modification: Acetylated

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: