TAPI-1 | 2068

Inhibitor of TNF-α processing (IC₅₀ = 100 nM), similar to TAPI-0 (Cat. No. 2067-1), but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α (IC₅₀ = 50-100 μM), APP (1-8 μM), IL6R (5- 10 μM), TNFRI (5 -10 μM), TNFRII (25 -50 μM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.

TAPI-I is aniInhibitor of TNF-α processing (IC₅₀ = 100 nM), similar to TAPI-0 (Cat. No. 2067-1), but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- α (IC₅₀ = 50-100 μM), APP (1-8 μM), IL6R (5- 10 μM), TNFRI (5 -10 μM), TNFRII (25 -50 μM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.

2068 | TAPI-1 DataSheet

Alternate Name/Synonyms: N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide; TNF protease inhibitor-0; C1

Appearance: White solid

Formulation: N/A

CAS Number: 171235-71-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₆H₃₇N₅O₅

Molecular Weight: 499.3

Cell-Permeable?: No

Purity: ≥95% by HPLC

Solubilities: DMSO and MEOH

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An inhibitor of TNF-α processing

MDL Number: N/A

PubChem CID: 9827273

SMILES: CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN

InChi: InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17 (3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17, 21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31, 32)/t17-,21?,22-/m0/s1

InChi Key: AWNBSWDIOCXWJW-OWHMDLSXSA-N