Tau (phospho Ser416) Antibody | 50-270

Tau (phospho Ser416) Antibody | 50-270 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat, Bovine, Chicken

Homology: N/A

Immunogen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser416 of rat tau.

Research Area: Neuroscience, Phospho-Specific

Tested Application: WB

Application: N/A

Specificiy: Specific for ~59, 65, 68k tau protein phosphorylated at Ser416.

Positive Control 1: N/A

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: 59/65/68

Validation: N/A

Isoform: N/A

Purification: Affinity Purified

Clonality: Polyclonal

Clone: N/A

Isotype: N/A

Conjugate: Unconjugated

Physical State: Liquid

Buffer: N/A

Concentration: N/A

Storage Condition: Tau (Ser416) antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year.

Alternate Name: N/A

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985) . Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990) . Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD) , Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995) . Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990) .