Tau (phospho-T231) polyclonal Antibody | BS4252

Tau (phospho-T231) polyclonal Antibody | BS4252 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB: 1:500~1:1000

Background: Tau, also known as MAPT (microtubule-associated protein tau), MAPTL, MTBT1 or TAU, is a 758 amino acid protein that localizes to the cytoplasm, as well as to the cytoskeleton and the cell membrane, and contains four Tau/MAP repeats. Expressed in neuronal tissue and existing as multiple alternatively spliced isoforms, Tau functions to promote microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity. Tau may also link microtubules with neural plasma membrane components and, addition to its role in microtubule stability, is also necessary for cytoskeletal plasticity.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-Tau (T231) polyclonal Antibody detects endogenous levels of Tau only when phosphorylated at Thr548, isoforms Tau-3 and isoforms Tau-4 phosphorylated at Thr231, and other isoforms phosphorylated at the corresponding Site.

Molecular Weight: 50 to 80 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; MAPT; MAPTL; MTBT1; TAU

Immunogen: Synthetic phosphopeptide derived from human isoforms Tau-4 around the phosphorylation site of Threonine 231.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: Phosphoinosotode Signaling,PI3K AKT signaling,Protein Kinase C Signaling,Immune Cell Signaling,Warburg Effect,Translational Contral elF4 and p70 S6 Kinase,Regulation of Microtubule Dynamics,T cell receptor signaling,Inhibition of Apoptosis,Insulin &Glucose Signaling,Cell Cycle Control G1 S Checkpoint,Adherens Junction signaling,Mitochondrial Control of Apoptosis,MTOR signaling,ErbB HER Signaling,