TCE35031 | B2599

TCE35031 is an analog of Thalidomide (Cat. No. 2020) commonly used as a precursor to PROTACs (proteolysis-targeting chimera technologies) that hijack cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

TCE35031 is an analog of Thalidomide (Cat. No. 2020) commonly used as a precursor to PROTACs (proteolysis-targeting chimera technologies) that hijack cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.

B2599 | TCE35031 DataSheet

Alternate Name/Synonyms: 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid, Carboxylic acid-functionalized Thalidomide, cereblon ligand for PROTACs

Appearance: Off-white solid

Formulation:

CAS Number: 1061605-21-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₂N₂O₇

Molecular Weight: 332.26

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A cereblon ligand for PROTACs

MDL Number:

PubChem CID: 25015436

SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)OCC(=O)O

InChi: InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21)

InChi Key: ZVWIXIGBWIEDFO-UHFFFAOYSA-N