TCS-359 | B2212

TCS-359 is a potent, ATP-competitive inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. It blocks the proliferation of myelomonocytic leukemia MV4-11 cells. TCS-359 synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.

TCS-359 is a potent, ATP-competitive inhibitor of FLT3 receptor tyrosine kinase (IC₅₀ = 42 nM) that displays selectivity over a range of other kinases. It blocks the proliferation of myelomonocytic leukemia MV4-11 cells. TCS-359 synergistically increases the cytotoxicity of an AF4-mimetic peptide against MV4-11 cells.

B2212 | TCS-359 DataSheet

Alternate Name/Synonyms: 2-(3,4-dimethoxybenzamido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide

Appearance: White solid

Formulation: N/A

CAS Number: 301305-73-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₂₀N₂O₄S

Molecular Weight: 360.43

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent, ATP-competitive FLT3 receptor tyrosine kinase inhibitor

MDL Number: N/A

PubChem CID: 1048845

SMILES: COC1=C(C=C(C=C1)C(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)OC

InChi: InChI=1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)

InChi Key: FSPQCTGGIANIJZ-UHFFFAOYSA-N