TEF (K224) polyclonal Antibody | BS2041

TEF (K224) polyclonal Antibody | BS2041 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: IHC

Application Range: IHC: 1:50~1:200

Background: TEF (thyrotrophic embryonic factor), also known as KIAA1655, is a 303 amino acid nuclear transcription factor that belongs to the bZIP (basic region/leucine zipper) family and PAR (proline and acidic amino acid-rich) subfamily. TEF binds DNA as either a homodimer or heterodimer, and is known to transactivate the TSHβ promoter. While broadly expressed in adults, TEF is only found in developing embryonic anterior pituitary gland. TEF accumulates according to a robust circadian rhythm and has also been found to inhibit cell growth by downregulating β chain expression of cytokine receptors. The functional domains of TEF are highly homologous with other members of the PAR-bZIP subfamily, including albumin D box-binding protein (DABP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP) .

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: TEF (K224) polyclonal Antibody detects endogenous levels of TEF protein.

Molecular Weight: ~ 33 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Thyrotroph embryonic factor; KIAA1655

Immunogen: Synthetic peptide, corresponding to amino acids 200-250 of Human TEF.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: