Terbinafine hydrochloride | B2657

Terbinafine hydrochloride is a selective TASK3 (TWIK-related acid-sensitive K⁺ channel 3, KCNK9, K2P9.1) activator (pEC₅₀ = 6.2). It displays >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also acts as a broad-spectrum antifungal agent; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

erbinafine hydrochloride is a selective TASK3 (TWIK-related acid-sensitive K⁺ channel 3, KCNK9, K2P9.1) activator (pEC₅₀ = 6.2). It displays >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC₅₀ = 5.69). Also acts as a broad-spectrum antifungal agent; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.

B2657 | Terbinafine hydrochloride DataSheet

Alternate Name/Synonyms: N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-1-naphthalenemethanamine, monohydrochloride

Appearance: White solid

Formulation:

CAS Number: 78628-80-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₅N.HCl

Molecular Weight: 327.89

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >30 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A broad-spectrum antifungal agent

MDL Number: MFCD00145430

PubChem CID: 5282481

SMILES: CC(C)(C)C#CC=CCN(C)CC1=CC=CC2=CC=CC=C21.Cl

InChi: InChI=1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;

InChi Key: BWMISRWJRUSYEX-SZKNIZGXSA-N