TERT (phospho-S824) polyclonal Antibody | AP0350

TERT (phospho-S824) polyclonal Antibody | AP0350 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB

Application Range: WB:1:500~1:1000

Background: Telomerase is an RNA-dependent DNA polymerase that catalyzes the addition of telomeric repeat sequences to chromosome ends. In most human somatic cells, telomerase activity is undetectable, and telomeres shorten with successive cell divisions. However, telomerase activity is detectable in immortal cells and in many human tumors. Two candidate mammalian telomerase proteins have been cloned. Human TP1 (for telomerase-associated protein 1), also designated TLP1 in rat (for telomerase protein component 1), is homologous to the Tetrahymena p80 telomerase protein and has been shown to interact with mammalian telomerase RNA. Human TERT (for telomerase reverse transcriptase), also designated hEST2 (for ever shorter telomeres), is homologous to the p123 telomerase protein from Euplotes and to the yeast Est2 protein. Expression of TERT mRNA has been shown to correlate with telomerase activity in various cell lines.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: p-TERT (S824) polyclonal Antibody detects endogenous levels of TERT protein when phosphorylated at Ser824.

Molecular Weight: ~ 127 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Telomerase reverse transcriptase; HEST2; Telomerase catalytic subunit; Telomerase-associated protein 2; TP2; TERT; EST2; TCS1; TRT

Immunogen: Synthetic phosphopeptide derived from human TERT around the phosphorylation site of Serine 824.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 104% (by SDS-PAGE) .

Pathway: Regulation of Apoptosis,Necrotic Cell Death,Inhibition of Apoptosis,Toll-like Receptor signaling,Death Receptor Signaling,