Tetrahydroxanthohumol | B3340

Tetrahydroxanthohumol (TXN) is a synthetic derivative of the flavonoid antioxidant Xanthohumol (Cat. No. 2258). TXN attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ. A peroxisome proliferator activated receptor gamma (PPARγ) competitive binding assay shows that TXN binds to PPARγ with an IC50 similar to pioglitazone and 8–10 times stronger than oleate. TXN has the potential to prevent or treat the neuro-metabolic impairments associated with HFD-induced obesity and metabolic syndrome (MetS) without risk of liver injury and adverse estrogenic effects.

Tetrahydroxanthohumol (TXN) is a synthetic derivative of the flavonoid antioxidant Xanthohumol (Cat. No. 2258). TXN attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ. A peroxisome proliferator activated receptor gamma (PPARγ) competitive binding assay shows that TXN binds to PPARγ with an IC50 similar to pioglitazone and 8–10 times stronger than oleate. TXN has the potential to prevent or treat the neuro-metabolic impairments associated with HFD-induced obesity and metabolic syndrome (MetS) without risk of liver injury and adverse estrogenic effects.

B3340 | Tetrahydroxanthohumol DataSheet

Alternate Name/Synonyms: TXN Tetrahydro-XN

Appearance: Solid

Formulation:

CAS Number: N/A

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₆O₅

Molecular Weight: 358.43

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A PPAR-gamma antagonist

MDL Number:

PubChem CID: N/A

SMILES: Oc1c(c(cc(O)c1CCC(C)C)OC)C(=O)CCc1ccc(O)cc1

InChi: InChI=1S/C21H26O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h5-6,8-9,12-13,22,24-25H,4,7,10-11H2,1-3H3

InChi Key: RNYWSIACWNMMEO-UHFFFAOYSA-N