TGX-221 | 1781

Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase β (IC₅₀ = 5 nM for p110β). Inhibits other PI3K isoforms at higher concentrations (IC₅₀ = 0.1 µM for p110δ, 5 µM for p110⍺, and 3.5 µM for p110ɣ).

TGX-221 is a potent, selective and ATP-competitive inhibitor of PI 3-kinase β (IC₅₀ = 5 nM for p110β). Inhibits other PI3K isoforms at higher concentrations (IC₅₀ = 0.1 µM for p110δ, 5 µM for p110⍺, and 3.5 µM for p110ɣ).

1781 | TGX-221 DataSheet

Alternate Name/Synonyms: (±)-7-Methyl-2-(morpholin-4-yl)-9-(1-phenylaminoethyl)-pyrido[1,2-a]-pyrimidin-4-one

Appearance: White solid

Formulation: N/A

CAS Number: 663619-89-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₁H₂₄N₄O₂

Molecular Weight: 364.44

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (10 mg/ml) or Ethanol (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of PI 3-kinase β

MDL Number: MFCD11113209

PubChem CID: 9907093

SMILES: CC1=CN2C(=O)C=C(N=C2C(=C1)C(C)NC3=CC=CC=C3)N4CCOCC4

InChi: InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3

InChi Key: CPRAGQJXBLMUEL-UHFFFAOYSA-N