Cell-permeable. A potent, selective and ATP-competitive inhibitor of PI 3-kinase β (IC₅₀ = 5 nM for p110β). Inhibits other PI3K isoforms at higher concentrations (IC₅₀ = 0.1 µM for p110δ, 5 µM for...
Cell-permeable. A potent and selective inhibitor of PI 3-K isoforms p110β/p110δ(IC₅₀ p110β = 0.13 µM, p110δ = 0.63 µM).TGX-115 is a potent and selective inhibitor of PI 3-K isoforms p110β/p110δ(IC₅₀...
TGX-155 is an inhibitor of phosphoinositide 3-kinase (PI3K). PI3Ks and their lipid product phosphatidylinositol-3,4,5-trisphosphate are involved in signaling events in many cellular processes...